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A. baumannii sepsis model bioluminescent strain BV645

in vitro

  • Engineering and use of the same drug resistant clinical A. baumannii strain for in vitro and in vivo applications
  • Bacteria with stable genomic bioluminescence label
  • Well characterized A. baumannii isolate to enable drug candidate screening and better understand infection models

High throughput in vivo model

  • Galleria mellonella infection model
  • Bioluminescence used for real-time analysis to better understand bacterial infections
  • Allows fast and cost-efficient pre-screening of drug candidates
  • Model validation with Tigecycline

In vivo sepsis model

  • A. baumannii sepsis infection model in neutropenic mice
  • Bioluminescence allows a real time analysis of bacterial load and infection progression
  • Model validation with tigecycline

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