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E. coli sepsis model bioluminescent strain BV1110

in vitro

  • Engineering and use of the same drug resistant clinical E. coli strain for in vitro and in vivo applications
  • Bacteria with stable genomic bioluminescence label
  • Well characterized E. coli isolate to enable drug candidate screening in different models

High throughput in vivo model

  • Galleria mellonella infection model
  • Bioluminescence used for real time analysis to better understand bacterial infections
  • Melanisation analysis to score larvae health
  • Allows fast and cost-efficient pre-screening of drug candidates
  • Model validation with Tigecycline

In vivo sepsis model

  • E. Coli sepsis model in neutropenic mice
  • Bioluminescence allows a real time analysis of bacterial load
  • Model validation with tigecyclin

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